私たちの考えるジャーナルクラブは、参加者が海外文献を和訳して発表し合うというような、単なる“抄読会”とは一線を画します。試験デザインから結論に至るまでの過程を常に批判的な視点でとらえ、同様の、あるいはそれ以上のエビデンスを自分たちの施設で獲得するにはプロトコールのどの部分を手直しすればよいかなど、現場主義に徹した討論の場を提供するのがJSEPTICのジャーナルクラブです。参考までに最近のレビューをお示しします。この臨場感に惹かれたなら、今すぐJSEPTICの門戸を叩いてください。
更新日： 2015/10/19
EGDT-ProMISe
Trial of early, goal-directed resuscitation for septic shock.
Mouncey PR, Osborn TM, Power GS, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015 Apr 2;372(14):1301-11. PMID: 25776532
更新日： 2015/10/19
敗血症の定義におけるSIRS criteria
Systemic inflammatory response syndrome criteria in defining severe sepsis.
Kaukonen KM, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015 Apr 23;372(17):1629-38. PMID: 25776936
更新日： 2014/12/15
EGDT-ARISE JSEPTIC
Goal-directed resuscitation for patients with early septic shock.
ARISE Investigators; ANZICS Clinical Trials Group. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014 Oct 16;371(16):1496-506. PMID: 25272316
更新日： 2014/12/08
敗血症と輸血の閾値
Lower versus higher hemoglobin threshold for transfusion in septic shock.
Holst LB, Haase N, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014 Oct 9;371(15):1381-91. PMID: 25270275
更新日： 2014/10/27
ARDSとスタチン製剤
Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5;370(23):2191-200.
更新日： 2014/06/02
敗血症プロトコール
A Randomized Trial of Protocol-Based Care for Early Septic Shock
The ProCESS Investigators. A Randomized Trial of Protocol-Based Care for Early Septic Shock. N Engl J Med 2014; 370:1683-1693
更新日： 2014/05/29
敗血症の血圧管理
High versus Low Blood-Pressure Target in Patients with Septic Shock
Pierre Asfar, M.D., Ph.D., Ferhat Meziani, M.D., et al. High versus Low Blood-Pressure Target in Patients with Septic Shock. N Engl J Med 2014; 370:1583-1593
更新日： 2012/10/22
PROWESS-SHOCK
Drotrecogin alfa (activated) in adults with septic shock.
Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012; 366: 2055-64. Epub 2012 May 22. PMID: 22616830
更新日： 2012/08/27
敗血症とHES
Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.
Perner A, Haase N, Guttormsen AB, et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med. 2012 ;367 :124-34. Epub 2012 Jun 27. PMID: 22738085
更新日： 2012/03/05
sepsisと心房細動
Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis.
Walkey AJ, Wiener RS, Ghobrial JM, et al. Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA. 2011 Nov 23;306(20):2248-54. Epub 2011 Nov 13. PMID: 22081378
更新日： 2012/03/05
sepsisと免疫抑制
Immunosuppression in patients who die of sepsis and multiple organ failure.
Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011; 306: 2594-605. PMID:22187279
更新日： 2012/01/23
新生児sepsisに対する免疫グロブリン
Treatment of neonatal sepsis with intravenous immune globulin.
INIS Collaborative Group, Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011; 365: 1201-11. PMID: 21962214
更新日： 2011/12/19
sepsisのweekly feedbackとsepsis response team (SRT)
Septic shock: a multidisciplinary response team and weekly feedback to clinicians improve the process of care and mortality.
Schramm GE, Kashyap R, Mullon JJ, et al. Septic shock: a multidisciplinary response team and weekly feedback to clinicians improve the process of care and mortality. Crit Care Med. 2011; 39: 252-8. PMID:21057312
更新日： 2011/10/31
septic shokの輸液療法
Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality.
Boyd JH, Forbes J, Nakada TA, et al. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011; 39: 259-65. PMID: 20975548
更新日： 2011/09/20
severe sepsisの予後
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna TJ, Ely EW, Smith DM, et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010; 304: 1787-94. PMID: 20978258
更新日： 2011/08/08
小児感染症と補液
Mortality after fluid bolus in African children with severe infection.
Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011; 364: 2483-95. PMID: 21615299
更新日： 2011/02/02
severe sepsisの予後
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna TJ, Ely EW, Smith DM, Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010; 304: 1787-94. PMID: 20978258
更新日： 2010/08/18
eritoran tetrasodium(TLR4 antagonist)はsepsisの予後を改善するか。
Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis
Tidswell M, Tillis W, Larosa SP, et al. Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med. 2010; 38: 306-8. PMID: 19661804
更新日： 2010/07/09
コルチコステロイドと強化インスリン療法
Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults: A Randomized Controlled Trial
Annane D, Cariou A, Maxime V, et al; COIITSS Study Investigators. Corticosteroid treatment and intensive insulin therapy for septic shock in adults. JAMA. 2010; 303: 341-348. PMID: 20103758
更新日： 2009/12/24
PMX (EUPHAS trial)
Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock: The EUPHAS Randomized Controlled Trial
Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009; 301: 2445-52. PMID: 19531784
更新日： 2009/12/07
sepsisに未分画ヘパリン
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.
Kruger PS, Freir NM, Venkatesh B, et al. A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med. 2009; 35: 717-21. Epub 2008 Nov 26. PMID: 19034423
更新日： 2009/11/24
sepsisにatorvastatin
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.
Kruger PS, Freir NM, Venkatesh B, et al. A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med. 2009; 35: 717-21. Epub 2008 Nov 26. PMID: 19034423
更新日： 2009/10/14
severe sepsis初期のCVVH
Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial
Payen D, Mateo J, Cavaillon JM, et al. Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med. 2009; 37: 803-10. PMID: 19237881
