更新日： 2017/02/13

呼吸不全とリハビリ

Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial.

Morris PE, Berry MJ, Files DC, et al. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. 2016 Jun 28;315(24):2694-702. PMID: 27367766

更新日： 2017/02/13

NPPVでのマスクとヘルメット

Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

Patel BK, Wolfe KS, Pohlman AS, et al. Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2435-41. PMID: 27179847

更新日： 2016/10/03

低リスク患者の抜管後のHFNC

Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial.

Hernández G, Vaquero C, González P, et al. Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial. JAMA. 2016 Apr 5;315(13):1354-61. PMID: 26975498

更新日： 2016/07/25

アセタゾラミドとCOPD

Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.

Faisy C, Meziani F, Planquette B, et al. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. JAMA. 2016 Feb 2;315(5):480-8. PMID: 26836730

更新日： 2016/07/25

腹部術後の呼吸不全

Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial.
Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial.

Hernández G, Vaquero C, González P, et al. Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial. JAMA. 2016 Apr 5;315(13):1354-61. PMID: 26975498

更新日： 2016/06/13

PAVは呼吸器離脱に適したモードか?

A Pilot Randomized Trial Comparing Weaning From Mechanical Ventilation on Pressure Support Versus Proportional Assist Ventilation.

Bosma KJ, Read BA, Bahrgard Nikoo MJ, et al. A Pilot Randomized Trial Comparing Weaning From Mechanical Ventilation on Pressure Support Versus Proportional Assist Ventilation. Crit Care Med. 2016 Jun;44(6):1098-108. PMID: 26807682

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更新日： 2015/07/20

高度炎症反応を伴う重症市中肺炎に対するステロイド投与

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.

Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015 Feb 17;313(7):677-86. PMID: 25688779

更新日： 2015/07/06

ARDSにおける駆動圧と予後

Driving pressure and survival in the acute respiratory distress syndrome.

Amato MB1, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome.N Engl J Med. 2015 Feb 19;372(8):747-55.PMID: 25693014

更新日： 2015/02/02

ARDSとスタチン

Simvastatin in the acute respiratory distress syndrome.

Simvastatin in the acute respiratory distress syndrome. N Engl J Med. 2014 Oct 30;371(18):1695-703. PMID: 25268516

更新日： 2014/08/29

肺塞栓と血栓溶解

Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.

Chatterjee S, Chakraborty A, Weinberg I et al. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014 Jun 18;311(23):2414-21. PMID: 24938564

更新日： 2014/08/29

中等度リスクの肺塞栓症と血栓溶解

Fibrinolysis for patients with intermediate-risk pulmonary embolism.

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014 Apr 10;370(15):1402-11.PMID: 24716681

更新日： 2013/10/07

ARDSに対する腹臥位

Prone Positioning in Severe Acute Respiratory Distress Syndrome

Claude Guérin, M.D., Ph.D., Jean Reignier, M.D., Ph.D., et al. Prone Positioning in Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2013 Jun 6; 368 (23): 2159-68. PMID: 23688302

更新日： 2013/08/12

COPD急性増悪とステロイド

Short-term vs. Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Pulmonary Disease The REDUCE Randomized Clinical Trial

Leuppi JD, Schuetz P et al. Short-term vs. Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Pulmonary Disease The REDUCE Randomized Clinical Trial. JAMA. 2013 June 5; 309(21): 2223-31 PMID: 23695200

更新日： 2012/08/13

ARDSの新しい定義 （The Berlin Definition）

Acute respiratory distress syndrome: the Berlin Definition.

ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307:2526-33. PMID: 22797452

更新日： 2012/04/16

ALIの経管栄養

Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial.

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, et al. Initial trophic vs full enteral feeding in patienJAMA. 2012; 307: 795-803. Epub 2012 Feb 5.ts with acute lung injury: the EDEN randomized trial. PMID: 22307571

更新日： 2012/02/27

ARDSにECMO

Extracorporeal membrane oxygenation for ARDS in adults.

Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011; 365: 1905-14. PMID: 22087681

更新日： 2012/02/21

ALIの栄養療法

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

Rice TW, Wheeler AP, Thompson BT, et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA. 2011; 306: 1574-81. Epub 2011 Oct 5. PMID: 21976613

更新日： 2012/02/21

H1N1インフルエンザとECMO

Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).

Noah MA, Peek GJ, Finney SJ, et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA. 2011 Oct 19;306(15):1659-68. Epub 2011 Oct 5. PMID: 21976615

更新日： 2011/12/26

ARDSから5年後

Functional disability 5 years after acute respiratory distress syndrome.

Herridge MS, Tansey CM, Matté A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011; 364: 1293-304. PMID: 21470008

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更新日： 2011/11/28

術後のNPPV

Non-invasive ventilation in postoperative patients: a systematic review.

Chiumello D, Chevallard G, Gregoretti C. et al. Non-invasive ventilation in postoperative patients: a systematic review. Intensive Care Med. 2011; 37: 918-29. Epub 2011 Mar 18. PMID: 21424246

更新日： 2011/10/03

早期の理学・作業療法

Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation.

Pohlman MC, Schweickert WD, Pohlman AS, et al. Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit Care Med. 2010; 38: 2089-94. PMID: 20711065

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更新日： 2011/09/26

市中肺炎とステロイド

Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial.

Meijvis SC, Hardeman H, Remmelts HH, Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011; 377: 2023-30. Epub 2011 Jun 1. PMID: 21636122

更新日： 2011/09/20

肺エコー

Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment.

Bouhemad B, Brisson H, Le-Guen M, et al. Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment. Am J Respir Crit Care Med. 2011; 183: 341-7. Epub 2010 Sep 17. PMID: 20851923

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更新日： 2011/09/05

ARDSの予後

Functional disability 5 years after acute respiratory distress syndrome.

Herridge MS, Tansey CM, Matté A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011; 364: 1293-304. PMID: 21470008

更新日： 2011/07/11

気切のタイミング2

Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial.

Trouillet JL, Luyt CE, Guiquet M, et al. Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial. Ann Intern Med. 2011 ;154 :373-83. PMID: 21403073

更新日： 2011/06/02

ウイーニングプロトコルは人工呼吸器装着期間を短縮するか？

Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis.

Blackwood B, Alderdice F, Burns K, et al. Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis. BMJ. 2011; 342: c7237. PMID: 21233157

更新日： 2011/02/02

腹臥位

Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial.

Taccone P, Pesenti A, Latini R, Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2009; 302: 1977-84. PMID: 19903918
第8回 JSEPTICセミナー

PPTデータ（ZIP圧縮）をダウンロード

更新日： 2010/08/18

気管切開は早期にすべき？

Early vs Late Tracheotomy for Prevention of Pneumonia in Mechaniclly Ventilated Adult ICU Patients: A Randomized Controlled Trial

Terragni PP, Antonelli M, Fumagalli R, et al. Early vs Late Tracheotomy for Prevention of Pneumonia in Mechaniclly Ventilated Adult ICU Patients: A Randomized Controlled Trial. JAMA. 2010; 303: 1483-9. PMID: 20407057

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更新日： 2010/07/16

pulmonary vascular dysfunctionの予後

Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury

Bull TM, Clark B, McFann K, et al. Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2010; 182: 1123-8. PMID: 20558628

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更新日： 2010/07/09

腹臥位

Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome A Randomized Controlled Trial

Taccone P, Pesenti A, Latini R, et al. Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2009; 302: 1977-84. PMID: 19903918

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更新日： 2010/05/24

高いPEEPか低いPEEPか

Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome: Systematic Review and Meta-analysis

Briel M, Meade M, Mercat A, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA. 2010; 303: 865-73. PMID: 20197533

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更新日： 2010/04/28

肺気腫、閉塞性肺疾患の進行は左室機能を悪くするか

Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling

Barr RG, Bluemke DA, Ahmed FS, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010; 362: 217-27. PMID: 20089972

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更新日： 2010/04/28

リクルートメント法

Recruitment manoeuvres for adults with acute lung injury receiving mechanical ventilation (Review)

Hodgson C, Keating JL, Holland AE, et al. ecruitment manoeuvres for adults with acute lung injury receiving mechanical ventilation. Cochrane Database Syst Rev. 2009; CD006667. PMID: 19370647

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更新日： 2010/04/05

プロカルシトニンはVAPでの抗生剤の量をへらせるか。

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

Stolz D, Smyrnios N, Eggimann P, et al. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study. Eur Respir J. 2009; 34: 1364-75. Epub 2009 Sep 24. PMID: 19797133

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更新日： 2010/03/01

ARDSにiLAを使用

Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study

Zimmermann M, Bein T, Arlt M, et al. Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study. Crit Care. 2009; 13: R10. Epub 2009 Jan 30. PMID: 19183475

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更新日： 2010/03/01

リクルートメント法

Recruitment Maneuvers for Acute Lung Injury

Fan E, Wilcox ME, Brower RG, et al. Recruitment maneuvers for acute lung injury: a systematic review. Am J Respir Crit Care Med. 2008; 178: 1156-63. Epub 2008 Sep 5. PMID: 18776154

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更新日： 2009/12/21

挿管患者のサクション

Endotracheal suctioning of the adult intubated patient---What is the evidence?

Pedersen CM, Rosendahl-Nielsen M, Hjermind J, et al. Endotracheal suctioning of the adult intubated patient--what is the evidence? Intensive Crit Care Nurs. 2009; 25: 21-30. Epub 2008 Jul 15. PMID: 18632271

Wordデータ（ZIP圧縮Wordデータ（ZIP圧縮）をダウンロード

更新日： 2009/12/21

人工呼吸患者の早期からの理学療法と作業療法

Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009; 373: 1874-82. Epub 2009 May 14. PMID: 19446324

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更新日： 2009/11/20

呼吸不全にECMO

Efficacy and economic assessment of conventional ventilatory support versus extracorporeal menbrane oxygenation for sever adult respiratory failure (CESAR) a multicentre randomised controlled trial

Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009; 374: 1351-63. Epub 2009 Sep 15. PMID: 19762075

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