更新日： 2015/11/30

潜在的に不適切な治療の要求

An Official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units.

Bosslet GT, Pope TM, Rubenfeld GD, et al. An Official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1318-30. PMID: 25978438

更新日： 2015/11/30

回収可能型IVCフィルター

Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial.

Mismetti P, Laporte S, Pellerin O, et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial.JAMA. 2015 Apr 28;313(16):1627-35. PMID: 25919526

更新日： 2015/09/07

TAVIから1年後

Clinical outcomes at 1 year following transcatheter aortic valve replacement.

Holmes DR Jr, Brennan JM, Rumsfeld JS, et al. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA. 2015 Mar 10;313(10):1019-28. PMID: 25756438

更新日： 2015/06/08

脳梗塞　血管内治療

Endovascular therapy for ischemic stroke with perfusion-imaging selection.
Randomized assessment of rapid endovascular treatment of ischemic stroke.
A randomized trial of intraarterial treatment for acute ischemic stroke.

更新日： 2015/02/02

ARDSとスタチン

Simvastatin in the acute respiratory distress syndrome.

Simvastatin in the acute respiratory distress syndrome. N Engl J Med. 2014 Oct 30;371(18):1695-703. PMID: 25268516

更新日： 2015/01/19

周術期のβブロッカー

Perioperative β blockade: guidelines do not reflect the problems with the evidence from the DECREASE trials.

Perioperative β blockade: guidelines do not reflect the problems with the evidence from the DECREASE trials. BMJ. 2014 Aug 29;349:g5210. PMID: 25172044

更新日： 2015/01/19

高容量ビタミンD

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014 Oct 15;312(15):1520-30. PMID: 25268295

更新日： 2014/10/27

ARDSとスタチン製剤

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.

National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5;370(23):2191-200.

更新日： 2014/08/29

肺塞栓と血栓溶解

Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.

Chatterjee S, Chakraborty A, Weinberg I et al. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014 Jun 18;311(23):2414-21. PMID: 24938564

更新日： 2014/08/29

中等度リスクの肺塞栓症と血栓溶解

Fibrinolysis for patients with intermediate-risk pulmonary embolism.

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014 Apr 10;370(15):1402-11.PMID: 24716681

更新日： 2014/03/03

Resuscitation Fluids

Resuscitation Fluids

John A. Myburgh, M.B., B.Ch., Ph.D., et al. Resuscitation Fluids. N Engl J Med 201 Sep 26; 3; 369:1243-1251. PMID: 24066745

更新日： 2013/08/12

COPD急性増悪とステロイド

Short-term vs. Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Pulmonary Disease The REDUCE Randomized Clinical Trial

Leuppi JD, Schuetz P et al. Short-term vs. Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Pulmonary Disease The REDUCE Randomized Clinical Trial. JAMA. 2013 June 5; 309(21): 2223-31 PMID: 23695200

更新日： 2012/11/05

頭蓋内圧亢進と高浸透圧療法

Hyperosmolar therapy for raised intracranial pressure.

Ropper AH. Hyperosmolar therapy for raised intracranial pressure. N Engl J Med. 2012 ;367 :746-52. PMID: 22913684

更新日： 2012/01/23

HUSに対するPEと免疫吸着

1）Management of an acute outbreak of diarrhoea-associated haemolytic uraemic syndrome with early plasma exchange in adults from southern Denmark: an observational study.
2）Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial.

更新日： 2012/01/23

新生児sepsisに対する免疫グロブリン

Treatment of neonatal sepsis with intravenous immune globulin.

INIS Collaborative Group, Brocklehurst P, Farrell B, King A, et al.  Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011; 365: 1201-11. PMID: 21962214

更新日： 2012/01/09

外傷性出血へのトラネキサム酸

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.

CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011; 377: 1096-101. PMID: 21439633

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更新日： 2011/11/28

ネシリチド

Effect of nesiritide in patients with acute decompensated heart failure.

O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011; 365: 32-43. PMID: 21732835

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更新日： 2011/10/03

早期の理学・作業療法

Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation.

Pohlman MC, Schweickert WD, Pohlman AS, et al. Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit Care Med. 2010; 38: 2089-94. PMID: 20711065

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更新日： 2011/09/26

多発外傷とステロイド

Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.

Roquilly A, Mahe PJ, Seguin P, Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA. 2011; 305: 1201-9. PMID: 21427372

更新日： 2011/09/26

市中肺炎とステロイド

Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial.

Meijvis SC, Hardeman H, Remmelts HH, Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011; 377: 2023-30. Epub 2011 Jun 1. PMID: 21636122

更新日： 2011/08/08

小児感染症と補液

Mortality after fluid bolus in African children with severe infection.

Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011; 364: 2483-95. PMID: 21615299

更新日： 2011/02/02

腹臥位

Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial.

Taccone P, Pesenti A, Latini R, Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2009; 302: 1977-84. PMID: 19903918
第8回 JSEPTICセミナー

PPTデータ（ZIP圧縮）をダウンロード

更新日： 2010/07/09

CDTモノクローナル抗体

Treatment with Monoclonal Antibodies against Clostridium difficile Toxins

Dawson AE, Shumak SL, Redelmeier DA. Treatment with Monoclonal Antibodies against Clostridium difficile Toxins. N Engl J Med. 2010; 362: 1445 ; author reply 1444-6. PMID: 20397290

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更新日： 2010/07/09

腹臥位

Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome A Randomized Controlled Trial

Taccone P, Pesenti A, Latini R, et al. Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2009; 302: 1977-84. PMID: 19903918

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