私たちの考えるジャーナルクラブは、参加者が海外文献を和訳して発表し合うというような、単なる“抄読会”とは一線を画します。試験デザインから結論に至るまでの過程を常に批判的な視点でとらえ、同様の、あるいはそれ以上のエビデンスを自分たちの施設で獲得するにはプロトコールのどの部分を手直しすればよいかなど、現場主義に徹した討論の場を提供するのがJSEPTICのジャーナルクラブです。参考までに最近のレビューをお示しします。この臨場感に惹かれたなら、今すぐJSEPTICの門戸を叩いてください。
更新日： 2015/10/19
EGDT-ProMISe
Trial of early, goal-directed resuscitation for septic shock.
Mouncey PR, Osborn TM, Power GS, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015 Apr 2;372(14):1301-11. PMID: 25776532
更新日： 2015/10/19
敗血症の定義におけるSIRS criteria
Systemic inflammatory response syndrome criteria in defining severe sepsis.
Kaukonen KM, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015 Apr 23;372(17):1629-38. PMID: 25776936
更新日： 2015/07/20
高度炎症反応を伴う重症市中肺炎に対するステロイド投与
Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.
Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015 Feb 17;313(7):677-86. PMID: 25688779
更新日： 2013/05/27
クロルヘキシジン清拭
Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection
Michael WC, Deborah SY, et al. Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection N Engl J Med. 2013;368:533-542
更新日： 2013/04/01
抗菌薬投与のタイミング
Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study.
Hranjec T, Rosenberger LH, Swenson B, et al. Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. Lancet Infect Dis. 2012;12:774-80. PMID: 22951600
更新日： 2013/02/04
MXFXとMEPMの併用
Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
Brunkhorst FM, Oppert M, Marx G, et al. Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA. 2012;307:2390-9. PMID: 22692171
更新日： 2012/01/23
HUSに対するPEと免疫吸着
1）Management of an acute outbreak of diarrhoea-associated haemolytic uraemic syndrome with early plasma exchange in adults from southern Denmark: an observational study.
2）Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial.
更新日： 2011/11/21
黄色ブドウ球菌菌血症に経食道エコーは必要か
Use of a simple criteria set for guiding echocardiography in nosocomial Staphylococcus aureus bacteremia.
Kaasch AJ, Fowler VG Jr, Rieg S, et al. Use of a simple Criteria Set for Guiding Echocardiography in Nosocomial Staphylococcus aureus Bacteremia. Clin Infect Dis. 2011; 53: 1-9. PMID: 21653295
更新日： 2011/10/24
薬剤コーティングカテーテル
Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience.
Ramos ER, Reitzel R, Jiang Y, et al. Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience. Crit Care Med. 2011; 39: 245-5. PMID: 21057308
更新日： 2011/09/26
市中肺炎とステロイド
Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial.
Meijvis SC, Hardeman H, Remmelts HH, Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011; 377: 2023-30. Epub 2011 Jun 1. PMID: 21636122
更新日： 2011/08/08
小児感染症と補液
Mortality after fluid bolus in African children with severe infection.
Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011; 364: 2483-95. PMID: 21615299
更新日： 2011/07/25
ICUにおける多剤耐性菌の感染拡大予防
1）Intervention to reduce transmission of resistant bacteria in intensive care.
2）Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections.
1）Huskins WC, Huckabee CM, O'Grady NP, et al. Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med. 2011; 364: 1407-18. PMID: 21488763
2）Jain R, Kralovic SM, Evans ME, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med. 2011; 364: 1419-30. PMID: 21488764
更新日： 2010/07/09
CDTモノクローナル抗体
Treatment with Monoclonal Antibodies against Clostridium difficile Toxins
Dawson AE, Shumak SL, Redelmeier DA. Treatment with Monoclonal Antibodies against Clostridium difficile Toxins. N Engl J Med. 2010; 362: 1445 ; author reply 1444-6. PMID: 20397290
更新日： 2010/05/24
Chlorhexidine-Alcoholとイソジン
Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
Darouiche RO, Wall MJ Jr, Itani KM, et al. Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis. N Engl J Med. 2010; 362: 18-26. PMID: 20054046
更新日： 2010/04/28
PRORATA trial
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
Bouadma L, Luyt CE, Tubach F, et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010; 375: 463-74. Epub 2010 Jan 25. PMID: 20097417
更新日： 2010/04/20
PRORATA trial
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
Bouadma L, Luyt CE, Tubach F, et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010; 375: 463-74. Epub 2010 Jan 25. PMID: 20097417
更新日： 2010/04/05
鼻腔に潜むS.aureusの殺菌とSSIの予防
Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus
Bode LG, Kluytmans JA, Wertheim HF, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010; 362: 9-17. PMID: 20054045
更新日： 2010/04/05
プロカルシトニンはVAPでの抗生剤の量をへらせるか。
Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
Stolz D, Smyrnios N, Eggimann P, et al. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study. Eur Respir J. 2009; 34: 1364-75. Epub 2009 Sep 24. PMID: 19797133
更新日： 2009/12/21
中心静脈ライン関連MRSA感染症
Methicillin-Resistant Staphylococcus aureus Central Line Associated Bloodstream Infections in US Intensive Cara Units, 1997-2007
Burton DC, Edwards JR, Horan TC, et al. Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007. JAMA. 2009; 301: 727-36. PMID: 19224749
更新日： 2009/12/07
プロカルシトニンと抗菌薬の使用期間
Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial
Hochreiter M, Köhler T, Schweiger AM, et al. Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial. Crit Care. 2009; 13: R83. Epub 2009 Jun 3. PMID: 19493352
更新日： 2009/11/20
中心静脈カテーテルカンジダのコロニゼーションは治療対象か。
Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals?
Pérez-Parra A, Muñoz P, Guinea J, et al. Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals? Intensive Care Med. 2009; 35: 707-12. Epub 2009 Feb 11. PMID: 19205662
