私たちの考えるジャーナルクラブは、参加者が海外文献を和訳して発表し合うというような、単なる“抄読会”とは一線を画します。試験デザインから結論に至るまでの過程を常に批判的な視点でとらえ、同様の、あるいはそれ以上のエビデンスを自分たちの施設で獲得するにはプロトコールのどの部分を手直しすればよいかなど、現場主義に徹した討論の場を提供するのがJSEPTICのジャーナルクラブです。参考までに最近のレビューをお示しします。この臨場感に惹かれたなら、今すぐJSEPTICの門戸を叩いてください。
更新日： 2016/10/03
心臓外科術後AFのコントロール
Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.
Gillinov AM, Bagiella E, Moskowitz AJ, et al. Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery. N Engl J Med. 2016 May 19;374(20):1911-21. PMID: 27043047
更新日： 2016/10/03
院外心停止とアミオダロン、リドカイン
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.
Kudenchuk PJ, Brown SP, Daya M, et al. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2016 May 5;374(18):1711-22. PMID: 27043165
更新日： 2016/07/25
アセタゾラミドとCOPD
Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
Faisy C, Meziani F, Planquette B, et al. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. JAMA. 2016 Feb 2;315(5):480-8. PMID: 26836730
更新日： 2016/06/13
重症敗血症に対する抗生剤持続投与
A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis.
Dulhunty JM, Roberts JA, Davis JS, et al. A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1298-305. PMID: 26200166
更新日： 2016/06/13
敗血症に合併した心房細動の治療
Practice Patterns and Outcomes of Treatments for Atrial Fibrillation During Sepsis: A Propensity-Matched Cohort Study.
Walkey AJ, Evans SR, Winter MR, et al. Practice Patterns And Outcomes Of Treatments For Atrial Fibrillation During Sepsis: A Propensity-matched Cohort Study. Chest. 2016;149(1):74-83. PMID: 26270396
更新日： 2016/05/02
感染症に対するアセトアミノフェン
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
Young P, Saxena M, Bellomo R, et al. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med. 2015 Dec 3;373(23):2215-24. PMID: 26436473
更新日： 2016/01/05
抗菌薬を減らすストラテジー
Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric).
Bretonnière C, Leone M, Milési C, et al. Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric). Intensive Care Med. 2015 Jul;41(7):1181-96. PMID: 26077053
更新日： 2016/01/05
周術期のワーファリンブリッジ
Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation.
Douketis JD, Spyropoulos AC, Kaatz S, et al. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation. N Engl J Med. 2015 Aug 27;373(9):823-33. PMID: 26095867
更新日： 2015/07/20
高度炎症反応を伴う重症市中肺炎に対するステロイド投与
Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.
Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015 Feb 17;313(7):677-86. PMID: 25688779
更新日： 2014/06/27
非心臓手術患者のアスピリン
Aspirin in patients undergoing noncardiac surgery
Devereaux PJ1, Mrkobrada M, et al. Aspirin in patients undergoing noncardiac surgery. N Engl J Med. 2014 Apr 17;370(16):1494-503 PMID24679062
更新日： 2013/07/08
周術期のβ遮断薬
Association of Perioperative β-Blockade With Mortality and Cardiovascular Morbidity Following Major Noncardiac Surgery
Martin J, M.D., Kwan Hur, PhD, et al. Association of Perioperative β-Blockade With Mortality and Cardiovascular Morbidity Following Major Noncardiac Surgery. JAMA. 2013 Apr 24; 309(16): 1704-13 PMID: 23613075
更新日： 2013/04/01
抗菌薬投与のタイミング
Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study.
Hranjec T, Rosenberger LH, Swenson B, et al. Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. Lancet Infect Dis. 2012;12:774-80. PMID: 22951600
更新日： 2013/02/04
MXFXとMEPMの併用
Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
Brunkhorst FM, Oppert M, Marx G, et al. Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA. 2012;307:2390-9. PMID: 22692171
更新日： 2012/10/22
PROWESS-SHOCK
Drotrecogin alfa (activated) in adults with septic shock.
Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012; 366: 2055-64. Epub 2012 May 22. PMID: 22616830
更新日： 2012/10/09
術中トラネキサム酸
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ. 2012 May 17;344:e3054. PMID: 22611164
更新日： 2012/09/18
心停止とアドレナリン
Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest.
Hagihara A, Hasegawa M, Abe T, et al. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012 Mar 21;307(11):1161-8. PMID: 22436956
更新日： 2012/07/23
FACE study （発熱と解熱薬）
Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study
Crit Care. 2012;16(1):R33.
更新日： 2012/05/14
頭部外傷とアマンタジン
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Giacino JT, Whyte J, Bagiella E, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012; 366: 819-26. PMID: 22375973
更新日： 2012/03/26
脳出血とワーファリン
Resumption of oral anticoagulation after warfarin-associated intracerebral hemorrhage: yes.
Steiner T. Resumption of oral anticoagulation after warfarin-associated intracerebral hemorrhage: yes. Stroke. 2011; 42: 3661-2. Epub 2011 Nov 3. PMID: 22052514
更新日： 2012/01/23
新生児sepsisに対する免疫グロブリン
Treatment of neonatal sepsis with intravenous immune globulin.
INIS Collaborative Group, Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011; 365: 1201-11. PMID: 21962214
更新日： 2012/01/09
外傷性出血へのトラネキサム酸
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011; 377: 1096-101. PMID: 21439633
更新日： 2011/11/28
ネシリチド
Effect of nesiritide in patients with acute decompensated heart failure.
O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011; 365: 32-43. PMID: 21732835
更新日： 2011/11/14
ICU入室と慢性疾患治療薬の中止
Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases.
Bell CM, Brener SS, Gunraj N, et al. Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases. JAMA. 2011; 306: 840-7. PMID: 21862745
更新日： 2011/10/31
心不全での利尿薬
Diuretic strategies in patients with acute decompensated heart failure.
Felker GM, Lee KL, Bull DA, et al. Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 2011; 364: 797-805. PMID: 21366472
更新日： 2011/09/26
多発外傷とステロイド
Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.
Roquilly A, Mahe PJ, Seguin P, Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA. 2011; 305: 1201-9. PMID: 21427372
更新日： 2011/09/26
市中肺炎とステロイド
Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial.
Meijvis SC, Hardeman H, Remmelts HH, Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011; 377: 2023-30. Epub 2011 Jun 1. PMID: 21636122
更新日： 2011/02/02
ドパミンとノルエピネフリンの比較
Comparison of dopamine and norepinephrine in the treatment of shock.
De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010; 362: 779-89. PMID: 20200382
第8回 JSEPTICセミナー
更新日： 2010/07/16
解離性くも膜下出血への硫酸マグネシウムの投与について
Prophylactic intravenous magnesium sulfate for treatment of aneurysmal subarachnoid hemorrhage: A randomized, placebo-controlled, clinical study
Westermaier T, Stetter C, Vince GH, et al. Prophylactic intravenous magnesium sulfate for treatment of aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, clinical study. Crit Care Med. 2010; 38: 1284-90. PMID: 20228677
更新日： 2010/07/09
コルチコステロイドと強化インスリン療法
Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults: A Randomized Controlled Trial
Annane D, Cariou A, Maxime V, et al; COIITSS Study Investigators. Corticosteroid treatment and intensive insulin therapy for septic shock in adults. JAMA. 2010; 303: 341-348. PMID: 20103758
更新日： 2010/05/24
血管外科手術後のフルバスタチン
Fluvastatin and Perioperative Events in Patients Undergoing Vascular Surgery
Schouten O, Boersma E, Hoeks SE, et al. Fluvastatin and perioperative events in patients undergoing vascular surgery. N Engl J Med. 2009; 361: 980-9. PMID: 19726772
更新日： 2010/05/24
Chlorhexidine-Alcoholとイソジン
Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
Darouiche RO, Wall MJ Jr, Itani KM, et al. Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis. N Engl J Med. 2010; 362: 18-26. PMID: 20054046
更新日： 2010/01/29
Dabigatranとワーファリン
Dabigatran versus Warfarin in Patients with Atrial Fibrillation
Nagarakanti R, Ezekowitz MD, Oldgren J, et al. Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion. Circulation. 2011 ;123: 131-6. Epub 2011 Jan 3. PMID: 21200007
更新日： 2010/01/20
Esomeprazoleの潰瘍予防
Intravenous Esomeprazole for Prevention of Recurrent Peptic Ulcer Bleeding
Thomson AB. Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding. Curr Gastroenterol Rep. 2009; 11: 339-41. PMID: 19765360
更新日： 2009/12/07
オピオイドが原因の便秘にMethylnaltrexone
Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness
Thomas J, Karver S, Cooney GA, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med. 2008; 358: 2332-43. PMID: 18509120
更新日： 2009/12/07
sepsisに未分画ヘパリン
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.
Kruger PS, Freir NM, Venkatesh B, et al. A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med. 2009; 35: 717-21. Epub 2008 Nov 26. PMID: 19034423
更新日： 2009/11/24
sepsisにatorvastatin
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.
Kruger PS, Freir NM, Venkatesh B, et al. A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med. 2009; 35: 717-21. Epub 2008 Nov 26. PMID: 19034423
更新日： 2009/11/20
neuromyopathy と corticosteroids
Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS
Hough CL, Steinberg KP, Taylor Thompson B, et al. Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med. 2009; 35: 63-8. Epub 2008 Oct 23. PMID: 18946661
更新日： 2009/11/05
CYP450に関係した薬剤
Mini-series: II. Clinical aspects. Clinically relevant CYP450-mediated drug interactions in the ICU
Spriet I, Meersseman W, de Hoon J, et al. Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU. Intensive Care Med. 2009; 35: 603-12. Epub 2009 Jan 9. PMID: 19132344
更新日： 2009/11/04
周術期のβ遮断薬
Perioperative β blockers in patients having non-cardiac surgery: a meta-analysis
Bangalore S, Wetterslev J, Pranesh S, et al. Perioperative beta blockers in patients having non-cardiac surgery: a meta-analysis. Lancet. 2008; 372: 1962-76. Epub 2008 Nov 13. PMID: 19012955
更新日： 2009/09/10
クロルヘキシジンスポンジとカテーテル感染
Chlorhexidine-Impregnated Sponges and Less Frequent Dressing Changes for Prevention of Catheter-Related Infections in Critically III Adults: A Randomized Controlled Trial
Timsit JF, Schwebel C, Bouadma L, et al. Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. JAMA. 2009 Mar 25;301(12):1231-41. PMID: 19318651
