About the Clinical Trial Group

Clinical Traila Group

There is not enough information available on whether routine treatments provided to patients with severe illness cause no harm to patients or healthcare professionals, and whether or not these treatments are improving outcomes. The JSEPTIC-CTG conducts multicenter clinical studies to determine clinical outcomes in patients because there are not sufficient data verifying the safety and efficacy of treatments used for many patients in different institutions.

About the JSEPTIC Clinical Traila Group

In 2010, we started the Nonprofit Organization, the Japanese Society of Education for Physicians and Trainees in Intensive Care Clinical Trial Group (JSEPTIC-CTG) with the motto “to start with what we can.” The purposes are 1) to initiate multicenter clinical studies that are capable of meeting global evaluation, 2) to support researchers who conduct multicenter studies, and 3) to train young investigators without institutional boundaries. Fortunately, the JSEPTIC-CTG meeting has been held a total of 23 times. The JSEPTIC-CTG has initiated 8 studies and has collaborated to conduct 3 global studies and 5 Japanese studies. The JSEPTIC-CTG has achieved a modest level of success, with 5 studies published in globally recognized medical journals and 2 studies published in Japanese journals.
In order to step forward into the future, the JSEPTIC-CTG is facing multiple challenges, such as maintaining the motivation of the investigators at institutions in helping with data input, and the funds and manpower required for the studies. It is essential to overcome these challenges; however, the most important thing is the passion of the principal investigators. We are working hard to bring ourselves closer to the level of the world-leaders in clinical studies such as the Canadian Critical Care Trials Groups (CCCTG) or clinical study groups in Australia and New Zealand.

Tetsuhiro Takei,
Chairperson of the JSEPTIC Clinical Traila Group
Department of Emergency and Critical Care Medicine, Yokohama City Minato Red Cross Hospital
November 5, 2015

Study Titles

Workload associated with renal replacement therapy during night shifts: a nationwide survey.

Requirement for a round-the-clock work system for clinical engineers, considering the starting time of an acute blood purification-related operation.

Assessment of the effects of heart rate control on the prognosis of patients with acute aortic dissection.
JSEPTIC-BW: A multicenter study of weight measurement in the intensive care unit (ICU).

Epidemiologic study of Mechanical Ventilation Practices in Japan: MVP investigation Neuromuscular Pathology in Critically Ill Patients: An Autopsy Study "NECROPSY Study".

A multicenter retrospective observational study of treatment effects on disseminated intravascular coagulation (DIC) due to sepsis.

JSEPTIC-non-ICU: A study of the management of critically ill patients in non-ICU hospital setting.

JSEPTIC-CRBSI: Assessment of the effects of chlorhexidine on venous catheter colonization.

A multicenter clinical study of the usefulness of procalcitonin, IL-6, HMGB1, and sCD14-ST in severity determination and infection diagnosis of acute pancreatitis.

JSEPTIC-BW: A multicenter study of weight measurement in the ICU.

J-SCRIPT: A cross-sectional survey of antimicrobial use in the ICU in Japan.